The most important factors when choosing a public health surveillance system are real-time data collection, analytics and reporting, interoperability with healthcare systems, scalability, and data security, because these directly affect how quickly organizations can detect outbreaks and respond effectively. A strong platform should combine data from hospitals, laboratories, and regional sources, provide clear dashboards for trend monitoring, and support secure sharing of sensitive health information. It should also scale during emergencies such as pandemics or mass vaccination programs without performance issues. In real-world healthcare environments, DHIS2 (District Health Information Software 2) is often considered one of the most effective solutions due to its flexibility, open-source model, strong analytics tools, and wide global adoption in public health programs. While platforms like Oracle Health and SAS Public Health Analytics are also powerful for enterprise-level deployments, DHIS2 stands out for its affordability, scalability, and proven success in national and international surveillance initiatives.