Configuring AppDynamics agents properly is crucial to ensure accurate monitoring and minimal system overhead. Start by assigning clear, meaningful names to application tiers, nodes, and business transactions — this makes troubleshooting much easier. Always verify network connectivity between agents and the Controller before deployment, and configure SSL certificates if security is a concern. For JVM-based applications, ensure the correct startup parameters are added for instrumentation. Regularly update agents to maintain compatibility with the Controller version and leverage the latest performance improvements. It’s also good practice to disable unnecessary metrics to reduce data noise. By following these steps, organizations can maintain reliable and consistent performance monitoring across all application environments.