Setting up Appium involves installing Node.js, Appium Server, and necessary drivers (UIAutomator2 for Android, XCUITest for iOS). For Windows, configuring Android Studio, Java JDK, and ADB paths is essential. On macOS, installing Xcode and Carthage is required for iOS automation. Testers also install Appium Inspector for element inspection. In New York, USA, developers often use tools like Homebrew or Chocolatey for quick installations. Once setup is complete, integrating Appium with IDEs like IntelliJ or VS Code ensures smooth script execution. Proper environment configuration ensures stable, reliable automation on both platforms.