Using Helm charts with Argo CD is a great way to manage complex Kubernetes applications. You can define Helm charts as part of your Git repository, and Argo CD will automatically render and apply them during deployment. This allows for parameterized, reusable configurations. Make sure to store values files separately for different environments (like dev, staging, and production) to keep things clean. Using version-controlled Helm charts also helps in tracking changes over time. For best results, validate your charts locally before pushing to Git. The integration of Helm and Argo CD offers both flexibility and automation, ideal for large-scale deployments.