JFrog Artifactory offers numerous best practices to ensure repositories remain organized, secure, and efficient. Teams should adopt a clear naming convention that reflects project structure and versioning. It’s essential to separate local, remote, and virtual repositories for clarity and access control. Using repository replication can enhance global collaboration, while setting permissions based on roles helps prevent accidental modifications. Automation through REST APIs and CI/CD integration ensures consistent artifact management. Regular cleanup policies, combined with checksum-based storage, help reduce disk usage. Ultimately, following these practices helps maintain a scalable, reliable, and secure artifact ecosystem that supports continuous delivery workflows effectively.