Choosing the right AWS region can make a big difference in performance and cost. The main thing is proximity to your users — pick a region closest to them to reduce latency. Then, compare pricing because AWS costs vary by location (for example, US-East is cheaper than some Asia regions). Also, consider data compliance — some industries require local data storage. AWS offers multiple regions like US-East (N. Virginia), EU (Frankfurt), and Asia Pacific (Mumbai), each with unique benefits. It’s also smart to check available services since not all are offered everywhere. Balancing speed, cost, and regulations helps you choose wisely.