Azure operates in over 60 regions worldwide, offering flexibility in selecting data centers for performance optimization. The best region depends on your target user base — for example, East US and West Europe provide excellent latency for North America and Europe, respectively. Azure’s proximity placement groups ensure minimal latency between related resources. Multi-region deployment improves reliability and failover readiness. When choosing a region, consider compliance, data residency, and cost factors. Consistent monitoring through Azure Network Watcher helps maintain optimal connectivity and application responsiveness across different geographies.